What is Nutragesic Nerve Health

NUTRAGESIC Nerve Health is a high potency formulation of five compounds including powerful B Vitamins and a proprietary blend combining two supplements to aid in the prevention and management of peripheral neuropathy and neuropathic pain. Conceived by a Yale University trained Pain Medicine Physician, Nutragesic was formulated and developed by a team of pharmaceutical and nutritional experts.


Vitamin B-12, or Methylcobalamin

is a water-soluble vitamin that is essential for the normal functioning of the brain and nervous system. Vitamin B-12 is important in the synthesis and maintenance of myelin, fatty sheaths that wrap around nerves and are essential for proper transmission of nerve impulses. Vitamin B-12 deficiency can result in peripheral neuropathy resulting in a disruption in nerve impulse propagation.

Vitamin B6, also as known Pyridoxine

helps the body metabolize fats and proteins, and facilitates the conversion of carbohydrates into fuel  (glucose), which is used to produce energy. Vitamin B 6 is essential for proper nerve function. It is used by the body to make several neurotransmitters, chemicals that carry signals from one nerve sell to another.   In adults neuropathy due to B6 deficiency starts with numbness, paresthesias, or burning pain in the feet which then ascends to affect the legs and eventually the hands. Vitamin B6 supplementation has been used to treat peripheral neuropathy and polyneuropathy due to Vitamin B6 deficiency.

Folate: Quatrefolic, also known as 5-Methyltetrahydrofolic acid ((6S)-5-MTHF),

is a unique form of the folate, another B-Vitamin that essential for the proper functioning of peripheral nerves. Unlike supplementary folic acid which requires enzymatic activation before it can be used by the body. (6S)-5-MTHF is able to penetrate the cell without requiring metabolism. This bioactive form of folate is seven times more bioavailable than folic acid, and has been shown to improve microvascular blood flow to peripheral nerves.

Benfotiamine, a derivative of Vitamin B-1 (Thiamine),

has been found to be a worthy adjuvant in the management of diabetic and peripheral neuropathy. Benfotiamine is a fat soluble analogue of the vitamin Thiamine (B1). This compound has been found to help ameliorate pain from peripheral neuropathy, including neuropathy due to diabetes. Benfotiamine reduces the proliferation of metabolites that contribute to the damage of micro vessels in the diabetic patient. The pathology of microvasculature damage is seen in diabetic retinopathy, nephropathy, and neuropathy.

Alpha-Lipoic Acid, also known as ALA

is a powerful antioxidant. Antioxidants  help protect cells from damage by attacking “free radicals”, waste products created when the body turns food into energy. ALA helps reduce hyperglycemia induced free radical formation. This ability to decrease free radicals is thought to help patients with diabetic peripheral neuropathy whose symptoms include pain, numbness, burning, and tingling in the arms and legs. ALA may not only serve as an analgesic treatment for peripheral neuropathic pain, but may also improve nerve function. Furthermore, taking alpha-lipoic acid may help another diabetes-related condition called autonomic neuropathy, which affects nerves to internal organs.


Peripheral nerves carry messages from the brain and spinal cord to the skin, muscles,

organs, and all other body tissues and systems. Damage or disease affecting these nerves is called peripheral neuropathy.

Peripheral neuropathy affects an estimated 20 million people in the United States. Symptoms of peripheral neuropathy can range from numbness or tingling, to pricking sensations (paresthesia), or muscle weakness. Areas of the body may become abnormally sensitive to stimuli such as touch or pain leading to an exaggeratedly intense or distorted experience. In such cases, pain may occur in response to a stimulus that does not normally provoke pain. Severe symptoms may include burning pain, muscle wasting, paralysis, or organ or gland dysfunction. Damage to nerves that supply internal organs may impair digestion, sweating, sexual function, and urination. In the most extreme cases, breathing may become difficult, or organ failure may occur.

There are a large number of potential causes of peripheral neuropathies. These include injury, trauma, or repetitive stress to nerves, metabolic and endocrine disorders, small vessel disease, autoimmune diseases, kidney disorders, tumors (both malignant and benign), infections, environmental and medical toxins, alcohol abuse, and genetic mutations.


DIABETIC NEUROPATHY:  Diabetic neuropathy is a common complication of type 1 and type 2 diabetes, and is among the most common types of peripheral neuropathies. Studies have shown that some 30% of hospitalized and 20% of community-dwelling diabetic patients have peripheral neuropathy.

Diabetic neuropathy can affect all peripheral nerves including, sensory nerves (i.e. pain fibers), motor nerves, and the nerves that control and regulate all internal organs and systems (the autonomic nervous system). In diabetic patients, it is believed that chronic elevated blood sugar causes damage to the small blood vessels that supply peripheral nerves. This impedes blood flow to these nerves, thus, leading to neuropathy.

Symptoms of diabetic neuropathy include but are not limited to-

  • Balance and gait disturbances
  • Numbness and tingling of the extremities
  • Burning or electric pain
  • Abnormal sensation to a body part (Dysesthesia)
  • Dysfunction of the nerves of the Gastrointestinal tract (Gastropareisis, Chronic Diarrhea,)
  • Erectile dysfunction
  • Loss of bladder control (Urinary Incontinence)
  • Vision changes
  • Dizziness
  • Muscle weakness
  • Delayed ejaculation (in males) / Absence of orgasm (in females)